Product Name :
PPP3CB Recombinant Rabbit Monoclonal Antibody [PSH0-21]
Predicted band size :
59 kDa
Observed band size :
59 kDa
Synonyms:
Calcineurin A beta antibody Calcineurin A2 antibody Calcineurin B, formerly antibody Calmodulin dependent calcineurin A subunit beta isoform antibody Calmodulin-dependent calcineurin A subunit beta isoform antibody CALNA 2 antibody CALNA2 antibody CALNB antibody CAM PRP catalytic subunit antibody CAM-PRP catalytic subunit antibody 展开
Function :
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca2+-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1.Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB. May play a role in skeletal muscle fiber type specification. Forms a complex composed of a calmodulin-dependent catalytic subunit (also known as calcineurin A) and a regulatory Ca2+-binding subunit (also known as calcineurin B).2-Methylpyrimidine Chemical name There are three catalytic subunits, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two regulatory subunits which are also encoded by separate genes (PPP3R1 and PPP3R2). In response to an increase in Ca2+ intracellular levels, forms a complex composed of PPP3CB/calcineurin A, calcineurin B and calmodulin. Interacts (via calcineurin B binding domain) with regulatory subunit PPP3R1/calcineurin B. Interacts (via calmodulin-binding domain) with calmodulin; the interaction depends on calmodulin binding to Ca2+. Interacts with SLC12A1.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform 265-318/524
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, ICC, FC
Coupling :
unconjugated
Clone number:
PSH0-21
RRID:
AB_3072409
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Price of 1505818-73-4 Aliquot store at -20℃ or -80℃.PMID:33712437 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 59 kDa
Positive control :
Mouse brain tissue lysate, Jurkat cell lysate, rat brain tissue lysate, rat skeletal muscle tissue, mouse skeletal muscle tissue, MCF-7.