Product Name :
2-APB (CAS 524-95-8)
Synonym :
2-Aminoethyl diphenylborinate
Application :
2-APB is a TRP activator that also blocks IP3R
CAS:
524-95-8
Purity:
≥98%
Molecular Weight:
225.09
Formula :
C14H16BNO
Physical state:
Solid
solubility :
Soluble in methanol (100 mg/ml), 95% ethanol (50 mg/ml), ethanol (10 mM), and DMSO (10 mM). Insoluble in water.
Shipping Condition :
Store at -20° C
Melting point:
101.86° C (Predicted)
SMILES:
B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
References:
:2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. | Hu, HZ., et al. 2004. J Biol Chem. 279: 35741-8. PMID: 15194687Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. | Xu, SZ., et al. 2005. Br J Pharmacol. 145: 405-14. PMID: 158061152-APB induces instability in rat left atrial mechanical activity. | Wolkowicz, PE., et al. 2007. J Cardiovasc Pharmacol. 49: 325-35. PMID: 175139522-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons. | Hagenston, AM., et al. 2009. Cell Calcium. 45: 310-7. PMID: 191006212-APB and capsazepine-induced Ca2+ influx stimulates clathrin-dependent endocytosis in alveolar epithelial cells. | Usmani, SM., et al.13039-63-9 manufacturer 2010. Cell Physiol Biochem. 25: 91-102. PMID: 20054148Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell. | Choi, KJ., et al. 2010. Korean J Physiol Pharmacol. 14: 105-11. PMID: 204733822-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm.[Ir(dtbbpy)(ppy)2]PF6 Data Sheet | Lefièvre, L.PMID:33663290 , et al. 2012. Biochem J. 448: 189-200. PMID: 229432842-Aminoethyl diphenylborinate (2-APB) analogues: regulation of Ca2+ signaling. | Ozaki, S., et al. 2013. Biochem Biophys Res Commun. 441: 286-90. PMID: 24036266Molecular mechanism of 2-APB-induced Ca influx in external acidification in PC12. | Takahashi, K., et al. 2014. Exp Cell Res. 323: 337-45. PMID: 24630903Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. | Gao, L., et al. 2016. Sci Rep. 6: 20791. PMID: 26876731Orai3 channel is the 2-APB-induced endoplasmic reticulum calcium leak. | Leon-Aparicio, D., et al. 2017. Cell Calcium. 65: 91-101. PMID: 28179072Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. | Schild, A., et al. 2020. Int J Mol Sci. 21: PMID: 327643532-Aminoethyl diphenylborinate inhibits bleomycin-induced skin and pulmonary fibrosis via interrupting intracellular Ca2+ regulation. | Hsu, WL., et al. 2021. J Dermatol Sci. 103: 101-108. PMID: 34315630